The appeal challenges Mohammed Asghar's conviction on a number of grounds, including the court's failure to consider any evidence of his mental health problems, which are detailed extensively in the National Health Service record of the UK, a statement released by his lawyers said.
Asghar was sentenced by a court in Rawalpindi last week for writing letters claiming to be a prophet of Islam.
His lawyers say that the appeal may take up to five years to be heard by Pakistan's high court, owing to a huge backlog of cases.
Having visited Asghar yesterday, they fear that his poor health means he is ill-equipped for a lengthy wait, they say.
Asghar remains severely mentally-ill, they report, but the prison authorities have not yet taken the necessary steps to provide him with the specialist medical treatment he urgently requires, the statement said.
British Prime Minister David Cameron has said he was "deeply concerned", and that "the Pakistani authorities can be in no doubt of the seriousness with which we take these developments" while a motion tabled in the Scottish Parliament calling on Pakistan to urgently review Asghar's case has received cross-party support.
Asghar's family allege he is being punished for a property dispute with one of his tenants.
Blasphemy is an extremely sensitive issue in Islamic Pakistan and insulting the Prophet Mohammed can carry the death penalty.
Pakistan's strict blasphemy laws have been criticised by rights groups, who say they are frequently misused to settle personal scores.
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